High amplitude high frequency oscillations during posttraumatic epileptogenesis

Objective: The aim of the present study was to investigate if high amplitude frequency oscillations (haHFOs) could be a biomarker posttraumatic epileptogenesis. Methods: After an initial craniotomy rats and inducement traumatic brain injury (TBI) through fluid percussion, recording microelectrodes were implanted bilaterally in different areas. Wideband electrical activity recorded intermittently from Day 1 TBI continued till week 21. HaHFO analysis performed during first 4 weeks whether occurrence this predicted development epilepsy or not. Results: Of 21 which received TBI, 9 became epileptic (E+) 12 did not (E−). HaHFOs observed prefrontal perilesional cortices, hippocampus, striatum both E+ E− group. In comparison E−, group showed significant increase rate haHFO after TBI. Conclusion: The results indicate that haHFOs electroencephalographic